If I had to pick 3, and these are the books that I have to have as soon as they come out, cannot hope to pick them up later, or wait for trades.

It would be

Walking Dead
Saga
Chew

in that order

My favorites are definitely Marvel followed by DC.
The Mighty Thor
Silver Surfer
X-Men
Avengers
Green Lantern

This was some of my pull list from almost 3 three ago. Lets see whats changed.
Witchblade- I still read this one but its not near the top of my favorite reads anymore. It's actually getting rather dull.
Green Hornet and Green Hornet Year One- Don't read neither one of them. Don't even know if Dynamite still does a Green Hornet book.
Project Superpowers season 2- well the title ended. I went from 3 Dynamite titles a month to none.
Thor- don't read anymore.
Green Lantern- This one is high on my favorite monthly reads.
Shield and The Web- Both books are long gone. DC didn't carry over the Red Circle books with the New 52.
Vengeance Of Moon Knight- *sighing* I wish there was still a Moon Knight monthly book.
Invincible Iron Man and Iron Man Legacy- Well Legacy is no longer around and I no longer read Invincible Iron Man.
Captain America- nope, not reading that book anymore either.

So out of that whole list I only read 2 titles presently that I did 3 years ago.

Now my favorite monthly reads are:
Green Lantern
Batman
Aquaman
Flash
Nightwing

Still pretty much all Indy

Walking Dead
Saga
I still read Chew, but not that crazy about it right now.

I am excited about Sheltered, have only read the first issue(may be the only one that is out), but I am really intrigued with that one.

I pretty much dropped all Marvel except Superior Spider-man, not that I am liking it...

And the only DC Books that I read each month are Swamp Thing, Animal Man and Batman.

Walking Dead
Saga
Locke & Key (almost over )
Manhattan Projects
East of West
New Avengers
Thor God of Thunder
Indestructible Hulk
Daredevil
Jupiter's Legacy


Invincible (reading in trades)
Rachel Rising (reading in trades)